HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-Formylbenzoate → Benzoic acid, 4-(1-hydroxypropyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-Formylbenzoate | HCID 15294 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzoic acid, 4-(1-hydroxypropyl)-, methyl ester | HCID 12105276 | — |
Reaction Steps
To a solution of 4-formyl-benzoic acid methyl ester (3.0 g, 18.3 mmol) in THF (10 mL) at 0° C. is added ethylmagnesium bromide (2M, 10 mL). After stirring at room temperature for 2 hours, it is quenched with saturated ammonium chloride, extracted with EtOAc. The organic is concentrated to give the titled compound as colorless oil: 2.2 g (62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609892B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-becc85dda06d4372a10918f50cb27241 |
| Source note | uspto-grants-2013_12 |