HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Formylbenzoylamino)propionic acid methyl ester → HCID 59518116, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Formylbenzoylamino)propionic acid methyl ester | HCID 16100325 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59518116 | HCID 59518116 | — |
Reaction Steps
To a solution of 3-(4-formyl-benzoylamino)-propionic acid methyl ester (1.2 g, 5 mmol) in THF (10 mL) at 0° C. is added ethylmagnesium bromide (2M, 1.1 mL). After stirring at room temperature for 2 hours, it is quenched with saturated ammonium chloride, extracted with EtOAc. The organic is concentrated to give the titled compound as colorless oil: 270 mg (15%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609892B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-39c77eaa6fdc485282f786255bd355f9 |
| Source note | uspto-grants-2013_12 |