反应详情

To the solution of 4-[1-(4-bromo-3-[1,3]dioxan-2-yl-phenoxy)-3-methyl-butyl]-benzoic acid methyl ester (1000 mg) in methanol (20 mL) is added sodium hydroxide (5 N aqueous, 2 mL) and stirred for 4 h. The reaction mixture is concentrated and acidified by 5 N HCl (2 mL), extracted with ethyl acetate. Combined organic layers are washed with water and brine, dried over sodium sulfate. Concentration gives the title compound (940 mg) as a white solid.

1. concentrationThe reaction mixture is concentrated
2. extractionextracted with ethyl acetate
3. washCombined organic layers are washed with water and brine
4. dry with materialdried over sodium sulfate
5. concentrationConcentration