Hydrochloric Acid → HCID 59518187, compound

Participants

Reaction Steps

Racemic 3-[4-{1-(2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-ylsulfanyl)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid ethyl ester (0.150 g, 0.240 mmol) is dissolved in tetrahydrofuran (1.0 mL) and sodium hydroxide (1.0 mL, 5N) is added. The reaction is monitored by HPLC, and upon complete conversion, the reaction is neutralized with hydrochloric acid (1.0 mL, 5N) and diluted with diethyl ether and water. The two phases are separated, and the organic layer is washed, dried, and concentrated. The title compound is used without further purification. MS (ES): 596.3 [M−H]−.

Provenance & Evidence