4-(Trifluoromethyl)phenylboronic acid → HCID 59518073, compound

HRID 1914356Notes

Reaction equation

HRID 1914356 reaction equation
C[O:2][C:3](=[O:30])[CH2:4][CH2:5][NH:6][C:7](=[O:29])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:19][C:20]2[CH:25]=[C:24]([CH3:26])[C:23](Br)=[C:22]([CH3:28])[CH:21]=2)[CH2:15][CH:16]([CH3:18])[CH3:17])=[CH:10][CH:9]=1.[F:31][C:32]([F:43])([F:42])[C:33]1[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=1>>[CH3:28][C:22]1[CH:21]=[C:20]([S:19][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:30])=[O:29])=[CH:9][CH:10]=2)[CH2:15][CH:16]([CH3:17])[CH3:18])[CH:25]=[C:24]([CH3:26])[C:23]=1[C:36]1[CH:37]=[CH:38][C:33]([C:32]([F:43])([F:42])[F:31])=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 67153612HCID 67153612, compound

Product 1

HCID 59518073HCID 59518073, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 358 starting from enantiomerically purified 3-{4-[1-(4-bromo-3,5-dimethyl-phenylsulfanyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester and 4-trifluoromethyl phenyl boronic acid. Isomer 1 MS: 542.2 [M−H]−; Isomer 2 MS: 542.2 [M−H]−.

Sources & evidence

ORD record
ord-1377a0516bd645f1817f85ed681ffaa6
Source dataset
uspto-grants-2013_12
Patent number
US08609892B2

Reaction notes

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