4-tert-Butylphenylboronic acid → HCID 59518044, compound

HRID 1914358Notes

Reaction equation

HRID 1914358 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][NH:6][C:7](=[O:31])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25](Br)=[C:24]([CH3:30])[CH:23]=2)[CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=1.[C:33]([C:37]1[CH:42]=[CH:41][C:40](B(O)O)=[CH:39][CH:38]=1)([CH3:36])([CH3:35])[CH3:34]>>[C:33]([C:37]1[CH:42]=[CH:41][C:40]([C:25]2[C:26]([CH3:28])=[CH:27][C:22]([S:21][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:32])=[O:31])=[CH:9][CH:10]=3)[CH2:15][CH2:16][C:17]([F:18])([F:19])[F:20])=[CH:23][C:24]=2[CH3:30])=[CH:39][CH:38]=1)([CH3:36])([CH3:35])[CH3:34]

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 67153631HCID 67153631, compound

Product 1

HCID 59518044HCID 59518044, compound

Procedure

The title compounds are prepared in a manner substantially similar to Example 367 starting from 3-{4-[1-(4-bromo-3,5-dimethyl-phenylsulfanyl)-4,4,4-trifluoro-butyl]-benzoylamino}-propionic acid methyl ester and 4-tert-butyl phenyl boronic acid. Isomer 1 MS: 570.2 [M−H]−; Isomer 2 MS: 570.2 [M−H]−.

Sources & evidence

ORD record
ord-3e91e5bd872348e7bce073e13fa853b0
Source dataset
uspto-grants-2013_12
Patent number
US08609892B2

Reaction notes

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