反应详情

N-Bromosuccinimide (1.22 g, 6.83 mmol) was added to a solution of ethyl-2-phenylthiophen-4-carboxylate (6.83 mmol) in acetic acid (10 mL) and stirred overnight. Toluene was added and the solvent was removed under vacuum. The product was purified by flash chromatography on silica, eluting with 0%-10% ethyl acetate in cyclohexane. The fractions containing the desired product were concentrated under vacuum to give the title compound (1.2 g). LCMS m/z 312.52 [M+H]+ R.T.=4.55 mins (Analytical Method 5).

1. customthe solvent was removed under vacuum
2. customThe product was purified by flash chromatography on silica
3. washeluting with 0%-10% ethyl acetate in cyclohexane
4. additionThe fractions containing the desired product
5. concentrationwere concentrated under vacuum