5-Pyridin-4-yl-thiophene-3-carboxylic acid ethyl ester → 5-Pyridin-4-yl-thiophene-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

5-Pyridin-4-yl-thiophene-3-carboxylic acid ethyl ester (1.4 mmol) was dissolved in 1 M aqueous sodium hydroxide (4 mL) and IMS (5 mL). The mixture was heated by microwave irradiation at 130° C. for 10 minutes, and then filtered. 1 N Hydrochloric acid was added and the resulting precipitate was isolated by filtration washed with water and dried to give the title compound as a white solid (0.15 g). LCMS m/z 205.96 [M+H]+ R.T.=1.51 min. (Analytical Method 5).

Provenance & Evidence