反应详情

温度

170 °C

5-(2-Bromo-acetyl)-thiophene-3-carboxylic acid methyl ester (0.4 g, 1.52 mmol) was dissolved in formamide (2 mL) and the tube purged with nitrogen and then sealed. The mixture was heated at 170° C. for 20 minutes. The resultant solution was diluted with HCl (1 M) and water and washed with ethyl acetate. The organic phase was evaporated then purified by chromatography on a silica II cartridge, eluting with 2:1 pentane:DCM to neat DCM, to give the side product, 5-oxazol-4-yl-thiophene-3-carboxylic acid methyl ester as white solid (0.049 g). LCMS m/z 251.35 [M+MeCN+H]+ R. T.=3.07 min (Analytical Method 6).

1. customthe tube purged with nitrogen
2. customsealed
3. additionThe resultant solution was diluted with HCl (1 M) and water
4. washwashed with ethyl acetate
5. customThe organic phase was evaporated
6. customthen purified by chromatography on a silica II cartridge
7. washeluting with 2:1 pentane