反应详情

温度

140 °C

5-(2-Bromo-acetyl)-thiophene-3-carboxylic acid methyl ester (0.261 g, 0.99 mmol) was dissolved in DMF (4 mL) and urea (0.131 g, 2.18 mmol) was added. The vessel was purged with nitrogen then sealed and heated by microwave irradiation at 140° C. for 10 minutes. The resultant mixture was diluted with water and extracted with ethyl acetate (×3). The organic phase was washed with lithium chloride (15% aqueous solution) then dried over sodium sulfate, filtered and evaporated to give crude 5-(2-amino-oxazol-5-yl)-thiophene-3-carboxylic acid methyl ester as an orange-brown solid (0.224 g).

1. customThe vessel was purged with nitrogen
2. customthen sealed
3. additionThe resultant mixture was diluted with water
4. extractionextracted with ethyl acetate (×3)
5. washThe organic phase was washed with lithium chloride (15% aqueous solution)
6. dry with materialthen dried over sodium sulfate
7. filtrationfiltered
8. customevaporated