HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-beta-aminophenethyl alcohol → (S)-2-(4-Fluoro-phenyl)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-beta-aminophenethyl alcohol | HCID 2724025 | — |
| Reactant | AC1Ofb5V | HCID 7048023 | — |
| Product | (S)-2-(4-Fluoro-phenyl)-piperidine | HCID 7022098 | — |
Reaction Steps
(S)-2-(4-Fluoro-phenyl)-piperidine (0.31 g) was prepared by analogous methods to those used in the preparation of (R)-2-(4-fluoro-phenyl)-piperidine but starting from (R)-(−)-2-phenylglycinol. LCMS m/z 180.12 [M+H]+ R.T.=1.75-2.1 min (Analytical Method 6), which was used in the synthesis of EE-50.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614209B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ddf513561a8c4b4cba72f955df7fd29e |
| Source note | uspto-grants-2013_12 |