Sodium hydride → HCID 178523756, compound

Participants

Reaction Steps

1-(1H-pyrazol-3-yl)imidazolidin-2-one (410 mg, 2.69 mmol) is placed in a microwave vial with acetonitrile (12 mL). NaH (60%, 108 mg, 2.69 mmol) is added and the reaction mixture is stirred at RT for 30 minutes. Trans-(4-(2-chloro-5-(trifluoromethyl)benzamido)cyclohexyl)methyl 4-methylbenzenesulfonate (1.20 g (0.20 mmol) is added and the mixture is heated using microwave radiation at 120° C. for 30 minutes. The mixture is partitioned between DCM and water. The organic phase is washed with water and brine, dried over MgSO4, filtered and the solvent was removed in vacuo. The product is purified by crystallisation (EtOAc with a small amount of MeOH) to afford the title compound.

Provenance & Evidence