Benzoyl chloride, 3-chloro- → HCID 178523759, compound

HRID 1914650Notes

Reaction equation

HRID 1914650 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20](Cl)=[O:21]>C(Cl)Cl>[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([NH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][NH:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:4][CH2:3]1)=[O:21]

Participants

4

Reactant 2

HCID 69252Benzoyl chloride, 3-chloro-HCID 59229932HCID 59229932, compound

Product 1

HCID 178523759HCID 178523759, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 7 mL vial equipped with magnetic stirrer bar is added (4-Amino-cyclohexylmethyl)-phenyl-amine (41 mg, 0.2 mmol), 3-chlorobenzoyl chloride (20 mg, 0.16 mmol) and DCM (2 mL) followed by trethylamine (42 μL, 0.3 mmol). The mixture is stirred at room temperature under nitrogen atmosphere for 3 hours. The mixture was then evaporated to dryness and purified directly by preparative HPLC, [MH+343.19].

Workup

  1. customTo a 7 mL vial equipped with magnetic stirrer bar
  2. customThe mixture was then evaporated to dryness
  3. custompurified directly by preparative HPLC, [MH+343.19]

Sources & evidence

ORD record
ord-ada1663355a543449b706969863d540d
Source dataset
uspto-grants-2013_12
Patent number
US08614213B2

Reaction notes

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