HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 5-Chloro-2-methylnicotinoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Chloro-2-methylpyridine-3-carboxylic acid | HCID 33778387 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-2-methylnicotinoyl chloride | HCID 53256665 | — |
Reaction Steps
5-Chloro-2-methyl-nicotinic acid (4.15 g, 24.2 mmol) is placed in a flask with DCM (100 mL) and oxalyl chloride (3.68 g, 29 mmol). DMF (200 μL) is added and the reaction mixture is stirred at r.t. for 1 hour (gas evolution). The mixture is filtered and the solvent is removed in vacuo to afford the title product which is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614213B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7e8e785170644488b3112ca10bb2ebd5 |
| Source note | uspto-grants-2013_12 |