HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1914731Generated: November 1, 2026
HCID 23092277, compound → ethyl 6-[(dimethylamino)methylene]-1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate
https://huagongshe.com/reaction/1914731
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 23092277 | HCID 23092277 | — |
| Reactant | ethyl 1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate | HCID 44236352 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | ethyl 6-[(dimethylamino)methylene]-1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate | HCID 67075650 | 90% |
Reaction Steps
16 g (72 mmol) of ethyl 1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate were dissolved in 100 mL of dimethylformamide and 32 mL of dimethylformamide ditertbutyl acetate were added. The mixture was stirred at 60° C. for 8 hours. The solvent was then evaporated in vacuo and the product crystallized from ethanol to give the title compound (17.96 g, 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08614220B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-9b07a7d228a04d529a9e5fc5f09e6bef |
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| Source note | uspto-grants-2013_12 |
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