Potassium Hydroxide → HCID 24993829, compound

HRID 1914736Notes

Reaction equation

HRID 1914736 reaction equation
[I:1][C:2]1[N:11]=[CH:10][C:9]2[CH2:8][CH2:7][C:6]3[C:12]([C:16]([O:18]CC)=[O:17])=[N:13][N:14]([CH3:15])[C:5]=3[C:4]=2[N:3]=1.[OH-].[K+:22]>C(O)C>[I:1][C:2]1[N:11]=[CH:10][C:9]2[CH2:8][CH2:7][C:6]3[C:12]([C:16]([O-:18])=[O:17])=[N:13][N:14]([CH3:15])[C:5]=3[C:4]=2[N:3]=1.[K+:22]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 44232943ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

Product 1

HCID 24993829HCID 24993829, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (384 mg, 1 mmol) was suspended in anhydrous ethanol (10 mL) and treated with a 1.5 M solution of potassium hydroxide in ethanol (6.6 mL, 10 mmol) at room temperature, overnight. The resulting precipitate was collected by filtration to give the title compound (323 mg, 82% yield) as a white solid.

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-fb53dab48f3d49d18d454e8a10a0b12f
Source dataset
uspto-grants-2013_12
Patent number
US08614220B2

Reaction notes

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