p-Toluenesulfonic acid → HCID 24992532, compound

Participants

Reaction Steps

0.085 g (0.15 mmol) of 8-(2-trifluoromethoxy-phenylamino)-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide were dissolved in 10 mL of ethanol and 28 mg of p-toluensulfonic acid (0.15 mmol) were added. The solution was stirred at room temperature overnight and the solvent removed in vacuo. The residue was purified by flash chromatography on silica gel (eluant: ethyl acetate/hexane 80/20) to afford 59 mg (90% yield) of the title compound.

Provenance & Evidence