1-Methyl-4-(4-methyl-3-nitrophenyl)piperazine → 2-Methyl-5-(4-methylpiperazin-1-yl)benzenamine

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-methyl-4-(4-methyl-3-nitro-phenyl)-piperazine (9.0 g, 38.29 mmol) in ethanol (100 mL) and cyclohexene (7 ml), Pd/C 10% (1.5 g) was added. The mixture was heated at 80° C. for 6 hours. The Pd was filtered from the reaction and the solvents were removed from the filtrate under reduced pressure. The crude was diluted with DCM and treated with HCl in dioxane; the precipitate was collected and washed with diethyl ether to give the final compound as a brown solid in quantitative yield.

Provenance & Evidence