Potassium Hydroxide → HCID 68668260, compound

HRID 1914761Notes

Reaction equation

HRID 1914761 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[C:16]2[C:15]3[N:14]=[C:13]([NH:17][C:18]4[CH:23]=[C:22]([N:24]5[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]5)[CH:21]=[CH:20][C:19]=4[O:31][C:32]([F:35])([F:34])[F:33])[N:12]=[CH:11][C:10]=3[CH2:9][CH2:8][C:7]=2[C:6]([C:36]([O:38]CC)=[O:37])=[N:5]1.[OH-].[K+:42]>C(O)C>[OH:1][CH2:2][CH2:3][N:4]1[C:16]2[C:15]3[N:14]=[C:13]([NH:17][C:18]4[CH:23]=[C:22]([N:24]5[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]5)[CH:21]=[CH:20][C:19]=4[O:31][C:32]([F:34])([F:35])[F:33])[N:12]=[CH:11][C:10]=3[CH2:9][CH2:8][C:7]=2[C:6]([C:36]([O-:38])=[O:37])=[N:5]1.[K+:42]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 59454315HCID 59454315, compound

Product 1

HCID 68668260HCID 68668260, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Ethyl 1-(2-hydroxy-ethyl)-8-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (1.7 g, 3.03 mmol) was suspended in ethanol 96% (50 mL) and treated with a 1.5 M solution of potassium hydroxide in ethanol (8 mL, 12 mmol) at room temperature, overnight. The precipitate was collected by filtration to give the title compound (1.54 g, 89% yield) as a white solid.

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-fa99396c747044a688be178ffa1884d9
Source dataset
uspto-grants-2013_12
Patent number
US08614220B2

Reaction notes

Loading…