Water → HCID 56681780, compound

Participants

Reaction Steps

A suspension of 8-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (488 mg, 1.0 mmol) and Cs2CO3 (490 mg, 1.5 mmol) was suspended in DMF (1 mL) and treated with 1-bromo-2-chloro-ethane (0.1 mL, 1.2 mmol) at room temperature. After 2 h the reaction mixture was poured into water and filtered, washed with water and dried to give the title compound (529 mg, 96% yield) as a white solid.

Provenance & Evidence