1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 56657856, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2-chloro-ethyl)-8-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (350 mg, 0.63 mmol) and DBU (3.5 mL) was heated to 80° C. for 1 h. After cooling the reaction mixture was poured into water and filtered. The crude solid was purified by flash chromatography on silica gel (eluant: DCM/MeOH 95/5) to afford 234 mg (71% yield) of the title compound.

Provenance & Evidence