HCID 59454390, compound → HCID 59454342, compound

Participants

Reaction Steps

A suspension of 5-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-trifluoromethoxy-phenylamine (0.3 g, 1.10 mmol), 10% Pd/C catalyst (100 mg) in EtOH (20 mL) was hydrogenated at 40 psi for 6 hours into a Parr apparatus. The mixture was filtered over a pad of celite, the solvent removed under vacuum and the crude residue purified by flash chromatography on silica gel (eluant: DCM/MeOH/NH3 95/05/005) to yield the title compound as a light brown solid (0.17 g, 56% yield).

Provenance & Evidence