Methanol → HCID 54583358, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-[5-((S)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (53 mg, 0.08 mmol) in DCM (1.7 mL) under an atmosphere of N2, at −78° C. 1M BCl3 in DCM (0.17 mL) was added dropwise. Under complete addition the solution was stirred at 0° C. for 30 min and at room temperature overnight. Then 2 mL of MeOH was added. The solvent was removed under reduced pressure and the residue was diluted with Et2O and decanted to give the desired compound in quantitative yield (46 mg) as a brown solid.

Provenance & Evidence