HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1914772Generated: November 1, 2026
Hydrochloric Acid → 5-Bromo-6-fluoro-1H-indazole
https://huagongshe.com/reaction/1914772
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone | HCID 59694475 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Bromo-6-fluoro-1H-indazole | HCID 46863923 | — |
Reaction Steps
A solution of 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone (24C, 5.0 g, 19.5 mmol) was treated with aq HCl (3M soln., 100 mL) and methanol (20 mL) and heated at 90° C. for 3 h, when the reaction turns homogenous. The reaction mixture was cooled to room temperature and basified with aq. NaOH. A colorless solid precipitated out which was filtered and dried to yield 5-bromo-6-fluoro-1H-indazole (24D)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08614229B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-6ed8b4a2edd64cc7b412005bb9f893a5 |
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| Source note | uspto-grants-2013_12 |
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