HCID 25053577, compound → HCID 178520481, compound

Participants

Reaction Conditions

Reaction Steps

To a 5 mL round-bottom flask equipped with a magnetic stir bar, was added enone 4n (27 μmol) in TFA (1 mL). The mixture was stirred 7 hours at 65° C. Then, the TFA was removed under reduced pressure and the crude was purified by chromatography (100% AcOEt) to give the pure product, as a white solid in 45% isolated. m.p. 1H NMR (300 MHz, d6-DMSO) δ 8.83 (s, 1H), 8.34 (d, 2H, J=8.9 Hz), 8.17 (d, 2H, J=8.8 Hz), 8.05 (d, 1H, J=16.1 Hz), 7.97 (d, 1H, J=15.9 Hz). 13C NMR (75 MHz, CDCl3) δ. HRMS (FAB) calcd for C18H15N4O3 ([M+H]+). found.

Provenance & Evidence