HCID 58034495, compound → HCID 58034374, compound

HRID 1914816Notes

Reaction equation

HRID 1914816 reaction equation
[NH2:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[CH2:12][OH:13]>C(Cl)(Cl)Cl.O=[Mn]=O>[NH2:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[CH:12]=[O:13]

Participants

4

Reactant 1

HCID 58034495HCID 58034495, compound

Product 1

HCID 58034374HCID 58034374, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6212ChloroformSolvent

Procedure

(7-amino-2-methylpyrazolo[1,5-a]pyrimidin-6-yl)methanol (1-1) (14.1 g, 79.2 mmol) was dissolved in anhydrous CHCl3 (500 mL) and TI-IF (250 mL). Activated MnO2 (68.9 g, 792 mmol) was added to the mixture, and the mixture was stirred for 16 h. After filtration through a plug of Celite pad, the filtrate was evaporated to give 7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carbaldehyde (1-2) as a yellowish solid.

Workup

  1. filtrationAfter filtration through a plug of Celite pad
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-913c11a72d0845c4ae40e1d1544feed3
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

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