Methyl 2-oxo-3-phenylpropanoate → HCID 178422280, compound

HRID 1914829Notes

Reaction equation

HRID 1914829 reaction equation
[CH3:1][C:2]1[CH:12]=[C:5]2[N:6]=[CH:7][C:8]([NH2:11])=[C:9]([NH2:10])[N:4]2[N:3]=1.[C:13]1([CH2:19][C:20](=[O:25])C(OC)=O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(O)=O>[CH3:1][C:2]1[CH:12]=[C:5]2[N:6]=[CH:7][C:8]3[C:9](=[N:10][C:20]([OH:25])=[C:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:11]=3)[N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 562359Methyl 2-oxo-3-phenylpropanoateHCID 58034299HCID 58034299, compound

Product 1

HCID 178422280HCID 178422280, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
65 °C

Procedure

A 40-mL scintillation vial containing Compound (10-3) (320 mg, 2.0 mmol, 1 eq.), methyl phenylpyruvate (360 mg, 2.2 mmol, 1.1 eq.), and 20% AcOH (20 mL) was stirred at room temperature for 1.5 hours and at 65° C. for 4 hours. The mixture was allowed to cool and the precipitated solid was filtered and washed successively with water (15 mL) and Et2O (2×10 mL). The solid was dried in vacuo to give Compound (10-4) as a yellowish solid.

Workup

  1. temperatureto cool
  2. filtrationthe precipitated solid was filtered
  3. washwashed successively with water (15 mL) and Et2O (2×10 mL)
  4. customThe solid was dried in vacuo

Sources & evidence

ORD record
ord-2b3a36ceb4764e7c9a670dd2a4cb9b3f
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

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