Sodium Methoxide → HCID 86671487, compound

HRID 1914867Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([N+:15]([O-:17])=[O:16])=[C:13](F)[CH:12]=[C:11]([F:19])[C:10]=2[F:20])=[C:4]([F:21])[CH:3]=1.[CH3:22][O-:23].[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([N+:15]([O-:17])=[O:16])=[C:13]([O:23][CH3:22])[CH:12]=[C:11]([F:19])[C:10]=2[F:20])=[C:4]([F:21])[CH:3]=1

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 86669362HCID 86669362, compound

Product 1

HCID 86671487HCID 86671487, compoundYield 81%

Procedure

Intermediate I-4a was prepared from (4-bromo-2-fluoro-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine (25 g, 0.069 mol) and sodium methoxide (18.6 g, 0.344 mol) using procedures analogous to Intermediate (I-3a) above to afford the product (81% yield).

Sources & evidence

ORD record: ord-fd84938a9de84c82990cdd4acfb7f1e5
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08614239B2

Reaction notes

Loading…