1-(4-Bromo-2-fluoro-phenyl)-6,7-difluoro-4-methoxy-5-nitro-1,3-dihydro-benzoimidazol-2-one → 5-Amino-1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-methoxy-1,3-dihydro-benzoimidazol-2-one

Participants

Reaction Steps

Intermediate I-12a was prepared from 1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-methoxy-5-nitro-1,3-dihydro-benzoimidazol-2-one (2 g, 0.00478 mol) and zinc powder (1.9 g, 0.0287 mol) using procedures analogous to those described above for the preparation of Intermediate I-11a to afford 1.7 g of the product (95% yield). H1NMR (DMSO-d6, 300 MHz): δ 11.52 (s, 114), 7.83 (dd, 1H), 7.62-7.55 (m, 2H), 4.99 (s, 2H), 3.75 (s, 3H).

Provenance & Evidence