HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 5-Amino-1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-hydroxy-1,3-dihydro-benzoimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 5-Amino-1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-methoxy-1,3-dihydro-benzoimidazol-2-one | HCID 68313402 | — |
| Product | 5-Amino-1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-hydroxy-1,3-dihydro-benzoimidazol-2-one | HCID 68313772 | 88% |
Reaction Steps
Intermediate I-14a was prepared from 5-amino-1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-methoxy-1,3-dihydro-benzoimidazol-2-one (I-12a: 1.7 g, 0.00438 mol) and borontribromide using procedures analogous to those used for the preparation of Intermediate I-13a in DCM (10.9 mL, 0.0109 mol) to afford 850 mg of the product (88% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614239B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-71c327e3ffaf493f9ae5ebc7fccffb99 |
| Source note | uspto-grants-2013_12 |