1-(Prop-2-en-1-yl)cyclopropane-1-sulfonyl chloride → 8-(1-Allyl-cyclopropanesulfonyl)-4,5-difluoro-6-(2-fluoro-4-iodo-phenyl)-6,8-dihydro-imidazo[4',5':3,4]benzo[1,2-d]oxazol-7-one

Participants

Reaction Steps

Intermediate I-21a was prepared from 4,5-difluoro-6-(2-fluoro-4-iodo-phenyl)-6,8-dihydro-imidazo[4′,5′:3,4]benzo[1,2-d]oxazol-7-one (I-15a: 250 mg, 0.561 mmol), 1-allyl-cyclopropanesulfonyl chloride (202 mg, 1.12 mmol), TEA (228 mL, 1.68 mmol) and DMAP (25 mg) using procedures analogous to those described above for Intermediate I-19a to afford 180 mg of the product (55.3% yield).

Provenance & Evidence