HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid | HCID 23192584 | — |
| Product | 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbonyl chloride | HCID 52920508 | — |
Reaction Steps
9.1 g of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid and 75.5 ml of thionyl chloride are refluxed for 1.5 hours. After cooling down, the reaction mixture is evaporated under vacuum to yield 10 g of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl chloride as a yellow oil. GC-MS; observed M/z:Molecular ion: (M+.)=212; fragments: (M+.—Cl)=177 and (M+.—F)=193.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614242B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-923a8cd0ec0649b48eb723aff63fb37b |
| Source note | uspto-grants-2013_12 |