HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → N,N-diethyl-(1-ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfon-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride | HCID 12138182 | — |
| Reactant | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl-methanesulfonyl)-piperidine-4-carboxylic acid methyl ester | HCID 12138183 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N,N-diethyl-(1-ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfon-amide | HCID 12138187 | 79% |
Reaction Steps
N,N-diethyl-(1-ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfon-amide (11) is prepared similarly to compound (10) using compound (9) with diethylamine. The product is isolated by column chromatography on silica gel with a gradient running from chloroform to ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614317B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-2b041758b0364e3096ec7d3ce3b6a36c |
| Source note | uspto-grants-2013_12 |