HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-N-octyl-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Octylamine | HCID 8143 | — |
| Reactant | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride | HCID 12138182 | — |
| Reactant | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl-methanesulfonyl)-piperidine-4-carboxylic acid methyl ester | HCID 12138183 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-N-octyl-methanesulfonamide | HCID 12138188 | 81% |
Reaction Steps
(1-Ethyl-2,2-dim ethyl-1,2-dihydroquinol-4-yl)-N-octyl-methanesulfonamide (12) is prepared similarly to compound (10) using compound (9) with n-octylamine. The product is isolated by column chromatography on silica gel with a gradient running from chloroform to ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614317B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-2e64f39aefa840b283fccdbefcbb1ea5 |
| Source note | uspto-grants-2013_12 |