Sulfuric Acid → HCID 86672519, compound

Participants

Reaction Conditions

Reaction Steps

Ethanol (25 mL) was added to a reaction vessel containing sorafenib free base (5 g). The reaction mixture was stirred for about 5 minutes. The temperature was raised to about 60° C. The reaction mixture was stirred for about 30 minutes. A sulphuric acid solution (sulphuric acid:ethanol:water: 0.57 mL:6 mL:19 mL) was added drop-wise. The reaction mixture was cooled to room temperature and stirred for about 12 hours. The reaction mixture was concentrated. The solid was filtered and dried under reduced pressure at about 50° C. for about 12 hours to obtain sorafenib sulphate.

Provenance & Evidence