5-(tert-Butyl)-3,3-dimethyl-6-nitrobenzofuran-2(3H)-one → 6-Amino-5-(tert-butyl)-3,3-dimethylbenzofuran-2(3H)-one

HRID 1915112Notes

Reaction equation

HRID 1915112 reaction equation
[C:1]([C:5]1[C:6]([N+:17]([O-])=O)=[CH:7][C:8]2[O:12][C:11](=[O:13])[C:10]([CH3:15])([CH3:14])[C:9]=2[CH:16]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[NH2:17][C:6]1[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:16][C:9]2[C:10]([CH3:15])([CH3:14])[C:11](=[O:13])[O:12][C:8]=2[CH:7]=1

Participants

4

Reactant 1

HCID 595441545-(tert-Butyl)-3,3-dimethyl-6-nitrobenzofuran-2(3H)-one

Product 1

HCID 595441486-Amino-5-(tert-butyl)-3,3-dimethylbenzofuran-2(3H)-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium on carbon (wet; 5 wt %) was placed into a round bottomed flask under nitrogen flow. 5-Tert-butyl-3,3-dimethyl-6-nitro-benzofuran-2-one (4.7 g, 17.85 mmol) was then added to the vessel. Methanol (120 mL) was then carefully charged to the vessel under nitrogen atmosphere. The vessel was then purged with N2, evacuated, then charged with hydrogen gas. The vessel was evacuated and re-charged with hydrogen gas, and then a continuous hydrogen gas stream was introduced. After completion, the reaction was filtered through Celite® and the cake was washed with MeOH (300 ml). The solvent was removed in vacuo and the product dried under high vacuum to give a white crystalline solid. 1H-NMR (400 MHZ, DMSO-d6) δ 7.05 (s, 1H); 6.48 (s, 1H); 5.02 (s, 2H, NH2); 1.34 (s, 6H); 1.30 (s, 9H)

Workup

  1. customThe vessel was then purged with N2
  2. customevacuated
  3. additioncharged with hydrogen gas
  4. customThe vessel was evacuated
  5. additionre-charged with hydrogen gas
  6. additiona continuous hydrogen gas stream was introduced
  7. filtrationAfter completion, the reaction was filtered through Celite®
  8. washthe cake was washed with MeOH (300 ml)
  9. customThe solvent was removed in vacuo
  10. customthe product dried under high vacuum
  11. customto give a white crystalline solid

Sources & evidence

ORD record
ord-5513de380d9243c38d8f3e869729b84d
Source dataset
uspto-grants-2013_12
Patent number
US08614325B2

Reaction notes

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