HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → Cinacalcet
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 3-(3-(Trifluoromethl)phenyl-N-(R)-1-(naphthalen-1-yl)ethyl)prop-2-en-1-amine | HCID 46194726 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Cinacalcet | HCID 156419 | 66.3% |
Reaction Steps
A mixture of compound (VI) (3.0 g), PdCl2 (0.01 g) in ethanol (10 mL) was heated up to reflux temperature and added in 5 hrs with formic acid (0.3 g). The mixture was then cooled down, diluted with toluene and washed with 30% w/w aqueous sodium hydroxide until neutrality. The organic layer was dried and concentrated to give Cinacalcet free base, compound (I) (2.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614353B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-1db06e5abed0444cb2afeb46359ee0a2 |
| Source note | uspto-grants-2013_12 |