HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 1-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one | HCID 27673 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 721847 | 115.7% |
Reaction Steps
To a solution of 1-(2,3-dihydro-indol-1-yl)-ethanone (58.0 g, 0.36 mol) in acetic acid (3000 mL) was added Br2 (87.0 g, 0.54 mol) at 10° C. The mixture was stirred at room temperature for 4 h. The precipitate was collected via filtration to give crude 1-(5-bromo-2,3-dihydro-indol-1-yl)-ethanone (100 g, 96%), which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614327B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-df723e54ee7a44b2ac350a8ecd8c4fe9 |
| Source note | uspto-grants-2013_12 |