HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Tert-butyl-2-chloro-5-nitro-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-Tert-butyl-2-chloro-5-nitrophenyl methyl carbonate | HCID 57470231 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Tert-butyl-2-chloro-5-nitro-phenol | HCID 57470232 | 72% |
Reaction Steps
Potassium hydroxide (10.1 g, 181 mmol) was added to 4-tert-butyl-2-chloro-5-nitrophenyl methyl carbonate (40.0 g, 139 mmol) in MeOH (100 mL). After 30 min, the reaction was acidified with 1N HCl and extracted with dichloromethane. The combined organic layers were combined, dried over Na2SO4 and concentrated under vacuum. The crude residue was purified by column chromatography (Pet. Ether/EtOAc, 30:1) to give 4-tert-butyl-2-chloro-5-nitro-phenol (23.0 g, 68% over 2 steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614327B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-fad7e78c334442a59c81dda599873233 |
| Source note | uspto-grants-2013_12 |