HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-Admantyl-4-methyl-5-nitrophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Admantyl-4-methyl-5-nitrophenyl ethyl carbonate | HCID 66686210 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Admantyl-4-methyl-5-nitrophenol | HCID 66685867 | 77% |
Reaction Steps
To a solution of 2-admantyl-4-methyl-5-nitrophenyl ethyl carbonate (378 mg, 1.05 mmol) in CH2Cl2 (5 mL) was added piperidine (1.0 mL). The solution was stirred at room temperature for 1 h, adsorbed onto silica gel under reduced pressure and purified by flash chromatography on silica gel (0-15%, EtOAc-Hexanes) to provide 2-admantyl-4-methyl-5-nitrophenol (231 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614327B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ae5615db00a94f4a9ee08a23c6d0d051 |
| Source note | uspto-grants-2013_12 |