反应详情

A flask charged with ethyl 8-bromo-5-methyl-4-oxo-1H-quinoline-3-carboxylate (895 mg, 2.89 mmol), sodium acetate (237 mg, 2.89 mmol) and Pd/C (180 mg, 1.69 mmol) was flushed under a N2 followed by evacuating under vacuum. Acetic acid (21 mL) was added under an inert atmosphere followed by evacuating under vacuum. The reaction was then stirred for 4 h in an atmosphere of H2. The reaction was filtered to remove the Pd catalyst and the solvent was evaporated to give ethyl 5-methyl-4-oxo-1H-quinoline-3-carboxylate (145 mg, 22%).

1. customwas flushed under a N2
2. customby evacuating under vacuum
3. additionAcetic acid (21 mL) was added under an inert atmosphere
4. customby evacuating under vacuum
5. filtrationThe reaction was filtered
6. customto remove the Pd catalyst
7. customthe solvent was evaporated