HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1915468Generated: October 31, 2026
Bromine → 2-Bromo-5-nitro-4-(trifluoromethyl)aniline
https://huagongshe.com/reaction/1915468
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Nitro-4-(trifluoromethyl)aniline | HCID 16432754 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-5-nitro-4-(trifluoromethyl)aniline | HCID 67246686 | 93.3% |
Reaction Steps
To a solution of 3-nitro-4-(trifluoromethyl)aniline (31.0 g, 150.4 mmol) in HOAc (200 mL) was added bromine (9.3 mL, 180.5 mmol) at 0° C. under an atmosphere of N2. The cooling bath was removed and the mixture was stirred at 20° C. for 1 h. The solvent was removed in vacuo to afford the crude product 2-bromo-5-nitro-4-(trifluoromethyl)aniline (40.0 g, 93%), which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08614327B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-5ac0c924fc3a4e65b60cd80391710708 |
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| Source note | uspto-grants-2013_12 |
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