Pyridine-2-carbonitrile → HCID 178420109, compound

Participants

Reaction Steps

0.09 ml triethylamine is added to a solution of 80 mg 4-(6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde in 3 ml methanol. To this solution a solution of 97 mg 2-(5-Piperidin-4H[1,2,4]triazol-3-yl)-pyridine*2HCl (prepared from tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate and pyridine-2-carbonitrile according to a procedure described in U.S. Pat. No. 4,011,218 or WO2005100344) in 3 ml DMF is added, followed by 0.04 ml glacial acetic acid and 114 mg NaBH(OAc)3. The resulting mixture is stirred at room temperature. Three additional portions of 2 equivalents NaBH(OAc)3 are added after 2, 4 and 5 hours.

Provenance & Evidence