HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1915551Generated: October 26, 2026
Phosphorus tribromide → 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine
https://huagongshe.com/reaction/1915551
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 1-[4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)phenyl]ethanol | HCID 68459225 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine | HCID 68461086 | — |
Reaction Steps
100 mg of the product of step 1 are dissolved in dichloromethane, cooled to 0° C. and 86 mg PBr3 are added. The mixture is stirred at room temperature for 24 h. Ice is added, the mixture extracted with dichloromethane and water, the organic layer are dried over Na2SO4 and the solvent is evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08614218B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-df4fc94a539749df904a08d91d7fdf73 |
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| Source note | uspto-grants-2013_12 |
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