HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-2-carbonitrile → HCID 178435853, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-2-carbonitrile | HCID 7522 | — |
| Reactant | tert-Butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate | HCID 22713165 | — |
| Reactant | 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine | HCID 68461086 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178435853 | HCID 178435853 | — |
Reaction Steps
To a solution of 0.2 g 2-(5-Piperidin-[1,2,4]triazol-3-yl)-pyridine*2HCl (prepared from tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate and pyridine-2-carbonitrile according to a procedure described in U.S. Pat. No. 4,011,218 or WO2005100344) in 7 ml DMF are added 120 mg of the product obtained in step 2 dissolved in 1 ml methanol and the mixture is stirred for 20 h. The mixture is concentrated and the crude product is purified by reversed phase HPLC (Water, 10 mM NH4COOH, pH 3.7/ACN)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614218B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-798ad4665b5e4a1296e78ac13e4e7652 |
| Source note | uspto-grants-2013_12 |