Pyridine-2-carbonitrile → HCID 178439989, compound

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Reaction Steps

2.2 ml triethylamine is added to a solution of 1.90 g 2-(5-piperidin-4H[1,2,4]triazol-3-yl)-pyridine*2HCl (prepared from tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate and pyridine-2-carbonitrile according to a procedure described in U.S. Pat. No. 4,011,218 or WO2005100344) in 140 ml methanol. To this solution a solution of 2.30 g 4-(2-isopropyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde in 140 ml DMF is added, followed by 2.4 ml glacial acetic acid and 3.0 g NaBH(OAc)3. The resulting mixture is stirred at room temperature. Four additional portions of 2 equivalents NaBH(OAc)3 are added after 2, 4, 5 and 8 hours. The solvent is removed by evaporation after 20 h and the residue is purified by chromatography on silica gel (dichloromethane/[dichloromethane+7M NH3 in methanol]) to yield the product.

Provenance & Evidence