HCID 178498471, compound → Methyl 5-amino-1H-pyrazole-3-carboxylate

HRID 1915612Notes

Reaction equation

HRID 1915612 reaction equation
[N+:1]([C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1

Participants

4

Reactant 1

HCID 178498471HCID 178498471, compound

Product 1

HCID 18445864Methyl 5-amino-1H-pyrazole-3-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 14.0 g methyl 3-nitro-1H-pyrazole-5-carboxylate in 200 ml methanol are added 1.2 g Pd/C (10% w/w). The mixture is stirred under H2-atmosphere at room temperature for 18 h. The mixture is filtrated over kieselgur. The filtrate is concentrated and the crude product is used without further purification.

Workup

  1. filtrationThe mixture is filtrated over kieselgur
  2. concentrationThe filtrate is concentrated
  3. customthe crude product is used without further purification

Sources & evidence

ORD record
ord-5673df33e4c04f1fa97b6356d01ad025
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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