HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1915655Generated: November 2, 2026
p-Fluoronitrobenzene → 1-Ethyl-4-(4-nitrophenyl)piperazine
https://huagongshe.com/reaction/1915655
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 1-Ethylpiperazine | HCID 79196 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Ethyl-4-(4-nitrophenyl)piperazine | HCID 2857549 | — |
Reaction Steps
To 4-fluoro-1-nitrobenzene (1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80° C. for 16 h. Concentrated the resultant mixture and partitioned between ethyl acetate and water. The organic layer was then washed with brine and dried with sodium sulfate and concentrated. Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08614330B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-2bc88bac22004d68ac3fa83149d7c415 |
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| Source note | uspto-grants-2013_12 |
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