1-Ethyl-4-(4-nitrophenyl)piperazine → 4-(4-Ethylpiperazin-1-yl)aniline

HRID 1915656Notes

Reaction equation

HRID 1915656 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]>CO.[Pd]>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:7][CH2:8]1)[CH3:2]

Participants

4

Reactant 1

HCID 28575491-Ethyl-4-(4-nitrophenyl)piperazine

Product 1

HCID 9367384-(4-Ethylpiperazin-1-yl)aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture containing 4-ethyl-1-(4-nitrophenyl)piperazine in methanol with catalytic amount of 10% Pd/C was hydrogenated to yield 4-(4-ethylpiperazinyl)phenylamine. MS: MH+=205.

Sources & evidence

ORD record
ord-a79613930b984e90bcd95dbbcbf493c4
Source dataset
uspto-grants-2013_12
Patent number
US08614330B2

Reaction notes

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