4-[2-(4-Nitrophenyl)ethyl]morpholine → 4-(2-Morpholinoethyl)aniline

HRID 1915658Notes

Reaction equation

HRID 1915658 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[N:12]1([CH2:11][CH2:10][C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 1

HCID 27974734-[2-(4-Nitrophenyl)ethyl]morpholine

Product 1

HCID 219550254-(2-Morpholinoethyl)aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture containing 4-[2-(4-nitrophenyl)ethyl]morpholine in methanol with catalytic amount of 10% Pd/C was hydrogenated to yield 4-(2-morpholin-4-ylethyl)phenylamine. MS: MH+=206.

Sources & evidence

ORD record
ord-c2f725b017ba4a9fb9229c45de6fd1d6
Source dataset
uspto-grants-2013_12
Patent number
US08614330B2

Reaction notes

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